Key result
Alcohol consumption was associated with a significant increase in relative whole blood, plasma, and serum viscosity, and osmotic fragility compared with non-alcohol consumers (P<0.05).
Why the study?
Does alcohol consumption alter haemorheology and osmotic fragility in subjects?
Case-Control (n=100)
Does alcohol consumption alter haemorheology and osmotic fragility in subjects?
Alcohol consumption is associated with significant increases in blood, plasma, and serum viscosity as well as osmotic fragility.
Alcohol consumption was associated with increased viscosity and osmotic fragility; leaves open causal cardiovascular effects and requires prospective confirmation.
Background: Alcohol consumption has been known to have physiological, mental, psychological and haematological effects on consumers. Aim and Objectives: This is study was aimed at assessing the effects of alcohol consumption on haemorrheology and osmotic fragility of alcoholconsumers in Nnewi metropolis as well as the gender and age variations. Study Design: This is a case control study. Method: A total of 100 subjects comprising 50 alcohol consumers (35 males and 15 females) and 50 non-alcohol consumers (35 males and 15 females) were recruited. The study subjects were tested for Relative Whole blood viscosity (RWBV), Relative plasma viscosity (RPV), Relative serum viscosity (RSV) and Osmotic fragility (Median Corpuscular Fragility (MCF) after obtaining ethical approval and informed consent of the subjects. RSV, RWBV and RPV were carried out by a modification of the capillary method of Reid and Ugwu (1987). Osmotic fragility was estimated using the method described by Dacie and Lewis (2012). Statistical Package for Social Sciences (SPSS) version 20 software was used for statistical analysis. Results: The results showed a significant increase in the mean of RWBV, RPV, RSV and MCF of alcohol consumers when compared with non-alcohol consumers (P<0.05). Similarly, the mean values of RWBV of male alcohol consumers were significantly higher than that of female alcohol consumers. However, there was no significant difference in the mean values of RWBV, RPV, RSV and MCF of alcohol consumers based on different age group (P>0.05). Also the mean values of RPV, RSV and MCF between male and female alcohol consumers showed no significant difference. Conclusion: Alcohol consumption results in significant alterations in haemorrheology and osmotic fragility of consumers.
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O et al. (2017) reported a case-control. Alcohol consumption vs. Non-alcohol consumers was evaluated on Relative whole blood viscosity, relative plasma viscosity, relative serum viscosity, and osmotic fragility (p=<0.05). Alcohol consumption was associated with a significant increase in relative whole blood, plasma, and serum viscosity, and osmotic fragility compared with non-alcohol consumers (P<0.05).
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