Key result
A new noninvasive device for recording ECG in conscious rats yielded heart rate, QTc, and QRS measurements that were not significantly different from those in anesthetized rats.
Absolute Event Rate: 365.8% vs 363.8%
p-value: p=>0.05
New rat ECG device feasible for recording; leaves open validation for HR variability in conscious models before research adoption.
AIM: Electrocardiogram (ECG) is an important tool for the study of cardiac electrophysiology both in human beings and experimental animals. Existing methods of ECG recording in small animals like rat have several limitations and ECG recordings of the anesthetized rat lack validity for heart rate (HR) variability analysis. The aim of the present study was to validate the ECG data from new device with ECG of anesthetized rat. MATERIALS AND METHODS: The ECG was recorded on student's physiograph (BioDevice, Ambala) and suitable coupler and electrodes in six animals first by the newly developed device in conscious state and second in anesthetized state (stabilized technique). RESULTS: < 0.05) in QTc, QRS, and HR recorded by new device and established device in rats. CONCLUSION: No previous study describes a similar ECG recording in conscious state of rats. Thus, the present method may be a most physiological and inexpensive alternative to other methods. In this study, the animals were not restrained; they were just secured and represent a potential strength of the study.
No takes yet. Share an insight, caveat, or question.
Kumar et al. (2017) studied Healthy (device validation) (n=6). Noninvasive ECG recording device in conscious state vs. ECG recording in anesthetized state was evaluated on Heart rate (bpm) (p=>0.05). A new noninvasive device for recording ECG in conscious rats yielded heart rate, QTc, and QRS measurements that were not significantly different from those in anesthetized rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: