Enantioselective Organocatalytic Addition of Nitroalkanes to Oxindolylideneindolenines for the Construction of Chiral 3,3‐Disubstituted Oxindoles

An enantioselective organocatalytic addition of nitroalkanes to oxindolylideneindolenines in the presence of bifunctional organocatalysts has been established to provide an efficient entry to 3,3‐disubstituted oxindole derivatives in high yields and with excellent enantioselectivities. The transformation has been applied to the preparation of the key intermediate for a formal total synthesis of (+)‐gliocladin C. magnified image