Key result
The nationwide prevalence of neuromyelitis optica spectrum disorder in South Korea was 3.56 per 100,000 individuals in 2017, with an incidence of 0.41 per 100,000 person-years.
Why the study?
Neuromyelitis optica spectrum disorder is a rare disease, but its prevalence and incidence had not yet been studied in Korea.
Observational (n=1,776)
This nationwide study provides epidemiological data on the prevalence and incidence of NMOSD in Korea, highlighting a higher incidence in females aged 30-59 years.
Provides first national NMOSD prevalence and incidence estimates in Korea; leaves open validation with prospective registries before guiding care.
Background: Although neuromyelitis optica spectrum disorder (NMOSD) is known to be a rare disease, its prevalence and incidence have not yet been studied in Korea. We performed a population-based study to examine the prevalence and incidence of NMOSD in Korea using data from the Korean National Health Insurance (NHI) claims database. Methods: Data from 2013 to 2017 were obtained, with a washout period set as 2013 and 2014. The prevalence and incidence of NMOSD in 2016 and 2017 were calculated using population census data. Subjects were divided into 5 groups at 15-year intervals, depending on the age at which the diagnostic code was entered. The relative risk (RR) for each age group was compared with the oldest ( 60 years) age group. Results: The overall prevalence was estimated to be 3.36 and 3.56 per 100,000 individuals, with an incidence of 0.41 and 0.65 per 100,000 individuals-year in 2016 and 2017, respectively. The mean age was 43.08 (standard deviation, 14.56) years, and the ratio of male to females was 1:4.7. The incidence was higher in female individuals aged between 30 and 59 years (RR, 2.8-3.05; P < 0.05). Conclusion: Nationwide prevalence of NMOSD in Korea was 3.36 and 3.56/100,000 and its incidence was 0.41 and 0.65/100,000-year in 2016 and 2017 respectively.
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Lee et al. (2020) conducted an observational in Neuromyelitis Optica Spectrum Disorder (NMOSD) (n=1,776). Population-based observation was evaluated on Overall prevalence of NMOSD per 100,000 individuals in 2017. The nationwide prevalence of neuromyelitis optica spectrum disorder in South Korea was 3.56 per 100,000 individuals in 2017, with an incidence of 0.41 per 100,000 person-years.
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