Key result
Left atrial appendage occlusion is highlighted as a strategy for patients with atrial fibrillation who have contraindications to oral anticoagulants and remain at significant risk of stroke.
Oral anticoagulant (OAC) therapy with vitamin K antagonists (VKAs) and new oral anticoagulants (NOACs) is highly effective in the prevention of stroke for patients with atrial fibrillation. The use of NOACs gave important benefits compared with VKAs in reducing the probability of major haemorrhagic events including intracranial bleeding with similar or better stroke prevention and easier management. Despite the efficacy of these treatments, many patients with atrial fibrillation still have contraindications to oral anticoagulants and would remain unprotected, leading to a significant risk of stroke and systemic thromboembolism.
No takes yet. Share an insight, caveat, or question.
Mazzone et al. (2020) conducted an editorial in Atrial fibrillation with contraindications to oral anticoagulants. Left atrial appendage occlusion was evaluated. Left atrial appendage occlusion is highlighted as a strategy for patients with atrial fibrillation who have contraindications to oral anticoagulants and remain at significant risk of stroke.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: