Key result
The highest tertiles of blood inflammatory indicators, including total leukocyte count (OR 1.78) and SIRI (OR 2.94), were significantly associated with a higher prevalence of multiple femoral plaques.
Why the study?
The associations between several blood inflammatory indicators and the risk of vascular plaques remain inconclusive.
Are elevated leukocyte and platelet-related inflammatory indicators associated with an increased risk of carotid and femoral plaques in rural Chinese residents?
Cross-Sectional (n=4,596)
Are elevated leukocyte and platelet-related inflammatory indicators associated with an increased risk of carotid and femoral plaques in rural Chinese residents?
Elevated blood inflammatory biomarkers, particularly composite indices like SIRI and SII, are associated with a higher prevalence of femoral artery plaques and stenosis in a rural Chinese population.
Answers are grounded in this paper and cite their sources.
Association of inflammatory indices with femoral plaques should not yet change practice; leaves open causal links and generalizability to other populations.
The associations between several blood inflammatory indicators and risk of vascular plaques remain inconclusive. A total of 4596 native rural residents in Southeast China were enrolled from the Fuqing cohort study. Blood cell counts and their composite indexes including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and 2 novel indicators (systemic immune inflammation index (SII) and systemic immune inflammation response index (SIRI)) were considered as inflammatory indicators. Common carotid and femoral intima-media thickness (IMT) and plaques were assessed using B-mode ultrasound. Unconditional or multinomial logistic regression was used to evaluate potential associations. The prevalence of multiple femoral plaques (defined as IMT ≥1.5 mm) was significantly higher among participants with the highest tertile of total leukocyte count (odds ratio, 1.78), neutrophil count (1.88), monocyte count (2.51), platelet count (1.68), NLR (1.93), PLR (1.57), SII (2.10), and SIRI (2.94). Higher levels of neutrophil count, platelet count, NLR, and SII were also found to have significant linear dose-response relationships with the prevalence of stenosis, especially in femoral arteries. In conclusion, several blood inflammatory biomarkers may contribute to, or are associated with, the presence of IMT ≥1.5 mm or stenosis especially in femoral arteries.
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Feng et al. (2022) conducted a cross-sectional in Carotid and femoral plaques (n=4,596). High blood inflammatory indicators (highest tertile) vs. Lower tertiles of blood inflammatory indicators was evaluated on Prevalence of multiple femoral plaques (IMT ≥1.5 mm) (OR 1.78). The highest tertiles of blood inflammatory indicators, including total leukocyte count (OR 1.78) and SIRI (OR 2.94), were significantly associated with a higher prevalence of multiple femoral plaques.
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