What question did this study set out to answer?

Investigate the protective efficacy of the dietary colorant crocin against cyclophosphamide-induced hepatotoxicity and oxidative tissue damage.

January 4, 2013Journal of Pharmacy and Pharmacology

Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines

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Authors

SJS. JnaneshwariUniversity of Mysore MHMahadevappa HemshekharRed River College MSM. Sebastin SanthoshMalabar Cancer Centre

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Implication

Animal study reveals crocin attenuates cyclophosphamide-induced hepatotoxicity in rats, highlighting its therapeutic potential against chemotherapy-associated oxidative stress.

Key Points

Investigate the protective efficacy of the dietary colorant crocin against cyclophosphamide-induced hepatotoxicity and oxidative tissue damage.
Wistar rats were administered a single intraperitoneal dose of cyclophosphamide (150 mg/kg) to trigger organ toxicity.
Treated animals received oral crocin at 10 mg/kg daily for six consecutive days following cyclophosphamide exposure.
Hepatoserum biochemistry, oxidative stress enzymes, inflammatory cytokine levels, and liver histological sections were analyzed.
A single cyclophosphamide injection significantly increased reactive oxygen species, lipid peroxidation, and protein oxidation while depleting antioxidant defenses, including reduced glutathione, catalase, and superoxide dismutase.
Cyclophosphamide administration substantially elevated liver serum markers, including aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase.
Oral crocin restored altered oxidative markers, antioxidant enzymes, and inflammatory cytokines toward normal levels and attenuated histological liver injury.

Cite This Study

Jnaneshwari et al. (2013) studied this question.

synapsesocial.com/papers/6a99131808ab6325d2e12000 https://doi.org/10.1111/jphp.12016

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Implication

Animal study reveals crocin attenuates cyclophosphamide-induced hepatotoxicity in rats, highlighting its therapeutic potential against chemotherapy-associated oxidative stress.

Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines

Discussion

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Implication

Key Points

Cite This Study

Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines

Discussion

Member takes

Implication

Key Points

Cite This Study

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