Key result
A positive exercise ECG stress test was not significantly associated with a higher rate of detectable high-sensitive troponin T compared to a negative test (53.1% vs 46.2%; P=0.09).
Cohort (n=2,780)
No
Absolute Event Rate: 53.1% vs 46.2%
p-value: p=0.09
In individuals undergoing annual health surveys, detectable high-sensitive troponin T levels are not significantly associated with positive exercise stress test results.
BACKGROUND: The exercise ECG stress test (EST) is still the first step of work-up in intermediate risk patients in many clinical scenarios. High-sensitive cardiac troponin T (hs-cTnT) elevation is related to future cardiovascular events in the general population and in patients with ischaemic heart disease. The relation between these 2 tests is not well described. MATERIALS AND METHODS: A total of 2780 participants from the Tel-Aviv Medical Center Inflammation Survey cohort (mean age 49 years, 79% men) were analysed. Multiple physiologic and metabolic parameters including hs-cTnT were collected. All participants completed an EST manually reviewed by a cardiologist. RESULTS: A positive EST was documented in 224 subjects (8%). The majority (91%) of participants with hs-cTnT levels of 5-14 ng/L had a negative EST as well as 89.3% of subjects with levels >14 ng/L. The proportion of subjects with a positive EST and detectable hs-cTnT levels (>5 ng/L) was not significantly greater compared to those with a negative EST (53.1% vs 46.2%, respectively, P = .09). CONCLUSION: Among subjects referred for EST as part of an annual health survey, we found no significant association between EST results to hs-cTnT detection.
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Brzezinski et al. (2018) conducted a cohort in Intermediate risk patients undergoing annual health survey (n=2,780). Positive exercise ECG stress test (EST) vs. Negative exercise ECG stress test was evaluated on Detectable hs-cTnT levels (>5 ng/L) (p=0.09). A positive exercise ECG stress test was not significantly associated with a higher rate of detectable high-sensitive troponin T compared to a negative test (53.1% vs 46.2%; P=0.09).
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