Key result
Analysis of fecal samples from asymptomatic rhesus macaques yielded 23 simian adenovirus isolates, with sequencing revealing high similarity to human adenovirus strains.
Observational (n=350)
Yes
Potential zoonotic reservoirs in asymptomatic primates; leaves open human infection risk and need for surveillance studies.
Adenoviruses can cause infectious diarrheal disease or respiratory infections in humans; 2 recent reports have indicated probable human infection with simian adenoviruses (SAdVs). To assess the possibility of animal-to-human transmission of SAdVs, we tested fecal samples from asymptomatic rhesus macaques housed in 5 primate facilities in the United States and cultured 23 SAdV isolates. Of these, 9 were purified and completely sequenced; 3 SAdV samples from the American Type Culture Collection (SAdV-6, SAdV-18, and SAdV-20) were also completely sequenced. The sequence of SAdV-18 was closely related to that of human adenovirus F across the whole genome, and the new isolates were found to harbor 2 fiber genes similar to those of human adenovirus (HAdV) strains HAdV-40 and HAdV-41, which can cause infectious diarrhea. The high prevalence of adenoviruses in fecal samples from asymptomatic rhesus macaques and the similarity of the isolates to human strains indicates the possibility of animal-to-human transmission of SAdVs.
No takes yet. Share an insight, caveat, or question.
Roy et al. (2012) conducted an observational in Asymptomatic rhesus macaques (fecal samples) (n=350). Adenovirus isolation and sequencing was evaluated on Isolation and sequencing of simian adenoviruses (SAdVs). Analysis of fecal samples from asymptomatic rhesus macaques yielded 23 simian adenovirus isolates, with sequencing revealing high similarity to human adenovirus strains.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: