What question did this study set out to answer?

To determine whether latent simian foamy virus proviruses found in peripheral blood represent the transcriptionally active viruses shed in the oral mucosa of rhesus macaques.

October 10, 2013Journal of VirologyOpen Access

Simian Foamy Virus Infection of Rhesus Macaques in Bangladesh: Relationship of Latent Proviruses and Transcriptionally Active Viruses

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Authors

KSKhanh Soliven XWXiaoxing Wang CSChristopher T Small

Discussion

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Overview

Comparative study reveals high concordance between latent and oral simian foamy virus strains in rhesus macaques, indicating blood proviruses reflect transmissible variants.

Key Points

To determine whether latent simian foamy virus proviruses found in peripheral blood represent the transcriptionally active viruses shed in the oral mucosa of rhesus macaques.
Sampled free-ranging rhesus macaques in Bangladesh (N=30).
Compared viral gag sequences from latent proviral DNA in peripheral blood mononuclear cells with active viral RNA from buccal swabs.
Evaluated viral RNA expression levels across age groups and screened for APOBEC3-induced hypermutation patterns.
Buccal mucosal viral strains matched latent blood proviral strains in 90% of the sampled macaques.
Levels of viral RNA in buccal swabs varied widely across individual animals, with higher viral loads detected in older macaques.
Evidence of APOBEC3-mediated mutation patterns appeared in viral gag sequences from both blood and oral mucosal tissues.

Cite This Study

Soliven et al. (2013) studied this question.

synapsesocial.com/papers/6aa57450bc2c7db7488e3efb https://doi.org/10.1128/jvi.01989-13

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October 10, 2013Journal of VirologyOpen Access

Simian Foamy Virus Infection of Rhesus Macaques in Bangladesh: Relationship of Latent Proviruses and Transcriptionally Active Viruses

View Full Paper

Ask AI

Bookmark

Authors

KSKhanh Soliven XWXiaoxing Wang CSChristopher T Small

Discussion

Member takes

Overview

Comparative study reveals high concordance between latent and oral simian foamy virus strains in rhesus macaques, indicating blood proviruses reflect transmissible variants.

Key Points

To determine whether latent simian foamy virus proviruses found in peripheral blood represent the transcriptionally active viruses shed in the oral mucosa of rhesus macaques.
Sampled free-ranging rhesus macaques in Bangladesh (N=30).
Compared viral gag sequences from latent proviral DNA in peripheral blood mononuclear cells with active viral RNA from buccal swabs.
Evaluated viral RNA expression levels across age groups and screened for APOBEC3-induced hypermutation patterns.
Buccal mucosal viral strains matched latent blood proviral strains in 90% of the sampled macaques.
Levels of viral RNA in buccal swabs varied widely across individual animals, with higher viral loads detected in older macaques.
Evidence of APOBEC3-mediated mutation patterns appeared in viral gag sequences from both blood and oral mucosal tissues.

Cite This Study

Soliven et al. (2013) studied this question.

synapsesocial.com/papers/6aa57450bc2c7db7488e3efb https://doi.org/10.1128/jvi.01989-13

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