Experimental study demonstrates efficient chemoenzymatic synthesis of heparan sulfate oligosaccharide analogues using sequential multienzyme systems, suggesting potential therapeutic applications.
Heparan sulfate analogues: Highly efficient one-pot multienzyme (OPME) chemoenzymatic systems for the activation and transfer of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) have been developed. They were applied to the sequential tailored synthesis of N-sulfated analogues of heparan sulfate oligosaccharides, which could be potential therapeutics.
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Chen et al. (2013) studied this question.
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