Practical limits of high speed chromatography: Evaluation with a computer based theoretical model of several commercially available gas chromatographs

Several commercially available chromatographs have been evaluated with respect to their ability to support high speed chromatography. Both autoinjection and trap and thermal pulse injection are both found to be suitable procedures to deliver the required narrow sample injection peak widths. However, even with the appropriate injectors in place, the systems are burdened with relatively slow data acquisition rates and large amplifier time constants that further degrade system performance and make them unsuitable for the high speed chromatography discussed herein. The study was conducted using a computer implemented model of a gas chromatograph's output.