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July 1, 1997Nucleosides and Nucleotides

Intracellular Metabolism and Action of an Antitumor Nucleoside, 2′-C-Cyano-2′-Deoxy-1-β- d -arabinofuranosylcytosine (CNDAC)

Atsushi Azuma Peng Huang Akira Matsuda William Plunkett

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Abstract

The mechanism of antitumor activity of 2′-C-cyano-2′-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC) has been examined. Intracellular metabolism of CNDAC using human leukemia cell lines are described. Incorporation of CNDAC triphosphate into DNA and the consequence of this incorporation have been evaluated in vitro using DNA primer extension assay with purified human DNA polymerase α and defined DNA primer/templates.

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Azuma et al. (1997) studied this question.

synapsesocial.com/papers/6a9917eeb554f1d3b1052606 https://doi.org/10.1080/07328319708006127

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Synapse has enriched 5 related papers. Consider them for comparative context:

1Nucleosides and nucleotides. 100. 2'-C-Cyano-2'-deoxy-1-.beta.-D-arabinofuranosylcytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleosideOriginal Research · 1991 · 85 citations
2Nucleosides and nucleotides. 122. 2'-C-Cyano-2'-deoxy-1-.beta.-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrumIn Vitro Study · 1993 · 69 citations
3Nucleosides and Nucleotides. 141. Chemical Stability of a New Antitumor Nucleoside, 2'-C-Cyano-2'-deoxy-1-.beta.-D-arabino-pentofuranosylcytosine (CNDAC) in Alkaline Medium: Formation of 2'-C-Cyano-2'-deoxy-1-.beta.-D-ribo-pentofuranosylcytosine (CNDC) and Its Antitumor ActivityOriginal Research · 1995 · 42 citations
42'-C-Cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC): A Mechanism-Based DNA-Strand-Breaking Antitumor Nucleoside1Original Research · 1995 · 34 citations
5Crystal and Solution Structure of 5′-O-(Guanosine-2′-O-Phosphonomethyl)Cytidine, an Isopolar Nonisosteric Phosphonate Analog Of GpCNucleosides and Nucleotides · Mon,

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