Key result
Hydrogen sulfide relaxed isolated rat vessel rings (EC50 1.79 × 10^-5 mol/L), an effect likely mediated by sulfhydration-associated phosphodiesterase 5A dimerization.
Population
Isolated rat thoracic aorta
Design
Preclinical
Authors
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In vitro results support mechanistic exploration in cardiovascular models; leaves open translation to clinical settings without in vivo validation.
Hydrogen sulfide exerts a vasorelaxant effect likely through sulfhydration-associated PDE 5A dimerization, which decreases PDE 5A activity and increases cGMP.
Sun et al. (2017) studied this question. Hydrogen sulfide (NaHS / GYY4137) was evaluated on Vasorelaxation. Hydrogen sulfide relaxed isolated rat vessel rings (EC50 1.79 × 10^-5 mol/L), an effect likely mediated by sulfhydration-associated phosphodiesterase 5A dimerization.
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