Immuno‐Polymeric Nanoparticles by Diels–Alder Chemistry

Hitting the target: Self-assembled polymeric nanoparticles from an amphiphilic copolymer were prepared with furan groups on the outer polyethylene glycol corona that were accessible for Diels–Alder reactions with maleimide-functionalized antibodies for the preparation of immuno-nanoparticles (see picture). The simple and clean coupling methodology allows facile modification of nanoparticles for use in targeted delivery to cancer cells.