A Comparison of Serum Aminopeptidase and Alkaline Phosphatase in the Detection of Hepatobiliary Disease in Anicteric Patients

Article1 July 1964A Comparison of Serum Aminopeptidase and Alkaline Phosphatase in the Detection of Hepatobiliary Disease in Anicteric PatientsALEXANDER M. RUTENBURG, M.D., BENJAMIN M. BANKS, M.D., ESTEBAN P. PINEDA, M.D., JULIUS A. GOLDBARG, M.D.ALEXANDER M. RUTENBURG, M.D.Search for more papers by this author, BENJAMIN M. BANKS, M.D.Search for more papers by this author, ESTEBAN P. PINEDA, M.D.Search for more papers by this author, JULIUS A. GOLDBARG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-1-50 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiseases of the liver, bile duct, or pancreas generally produce an increase in serum aminopeptidase activity (LAP) (1-14). This increase signifies excretory blockade (1, 6). The same is true of serum phosphatase, but an increase in this enzyme can also be caused by increased osteoblastic activity (15-26).Previous reports (1, 3, 4, 6-8, 12, 27-34) have dealt with these serum enzymes in jaundiced patients, but the data on anicteric patients (3-6, 27, 28) are sparse. The purpose of the present report is to assess the relative merits of the serum values of these enzymes in 1,332 anicteric patients, 400 in...References1. RUTENBURGGOLDBARGPINEDA AMJAEP: Leucine aminopeptidase activity: observations in patients with cancer of the pancreas and other diseases. New Eng. J. Med. 259: 469, 1958. CrossrefMedlineGoogle Scholar2. ARSTMANNINGDELP HERTM: Serum leucine aminopeptidase activity: findings in carcinoma of the pancreas, pregnancy and other disorders. Amer. J. Med. Sci. 238: 598, 1959. CrossrefMedlineGoogle Scholar3. HAMMONDROSENAKKHOO JBBDEC: The diagnostic value of determinations of serum leucine aminopeptidase concentrations in carcinoma of the pancreas. 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GOLDBARG, M.D.Affiliations: Boston, MassachusettsFrom the Yamins Laboratory for Surgical Research, Beth Israel Hospital and the Departments of Surgery, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts.This investigation was supported by research grants and a contract from the National Cancer Institute, National Institutes of Health, Department of Health, Education, and Welfare, Bethesda, Maryland.Requests for reprints should be addressed to Alexander M. Rutenburg, M.D., Harvard Medical School, Beth Israel Hospital, 330 Brookline Avenue, Boston, Massachusetts 02215. 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