Incidence of Propofol Infusion Syndrome during Noninvasive Radiofrequency Ablation for Atrial Flutter or Fibrillation
Why the study?
Does prolonged propofol infusion increase the incidence of metabolic acidosis (propofol infusion syndrome) in patients undergoing radiofrequency ablation for atrial flutter or fibrillation?
Population
55 patients undergoing nonsurgical, catheter radiofrequency ablation for atrial flutter or fibrillation who…
Comparison
Prolonged, high-dose propofol infusion during… vs No propofol.
Design
Cohort
Follow-up
Intraprocedural
Authors
Discussion
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Implication
May signal higher metabolic acidosis risk with prolonged propofol in ablation; hypothesis-generating and requires prospective validation.
Structured PICO
Does prolonged propofol infusion increase the incidence of metabolic acidosis (propofol infusion syndrome) in patients undergoing radiofrequency ablation for atrial flutter or fibrillation?
P
Population
55 patients undergoing nonsurgical, catheter radiofrequency ablation for atrial flutter or fibrillation who received propofol and had an arterial blood gas drawn, and 267 carotid endarterectomy patients who did not receive propofol.
I
Intervention
Prolonged (7 hours), high-dose (20 mg/kg) propofol infusion during radiofrequency ablation.
C
Comparator
No propofol (carotid endarterectomy patients who had an arterial blood gas drawn after anesthetic induction and before surgical incision).
O
Outcome
Incidence of metabolic acidosis (prospectively defined as base excess -2 or less).safety
Prolonged, high-dose propofol infusion during radiofrequency ablation is associated with a significantly increased incidence of metabolic acidosis, suggesting propofol infusion syndrome is not rare in this setting.
Limitations
- Retrospective nature
- Lack of baseline arterial blood gas data
Cite This Study
Cravens et al. (2007) studied this question.