August 1, 1994Anesthesia & Analgesia
Changes in Heart Rate Variability Under Propofol Anesthesia
Why the study?
Does propofol anesthesia alter heart rate variability and autonomic tone in women undergoing laparoscopy?
Population
10 women undergoing laparoscopy for benign disease
Comparison
Propofol anesthesia, with subsequent… vs Baseline and sequential time periods
Design
Case_series
Follow-up
Perioperative period
Authors
Discussion
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Implication
May predispose to bradycardia via relative parasympathetic preservation during laparoscopy; hypothesis-generating case report requiring prospective validation.
Structured PICO
Does propofol anesthesia alter heart rate variability and autonomic tone in women undergoing laparoscopy?
P
Population
10 women undergoing laparoscopy for benign disease
I
Intervention
Propofol anesthesia (intravenous bolus followed by infusion), with subsequent administration of relaxants (succinylcholine or vecuronium) and opioids (alfentanil or fentanyl), intubation, and laparoscopic trocar placement with carbon dioxide insufflation
C
Comparator
Baseline (preinduction) and sequential time periods (postinduction, postintubation, posttrocar placement)
O
Outcome
Heart rate variability spectra (total, high-frequency, and low-frequency power) measured via ambulatory electrocardiogram monitoringsurrogate
Propofol anesthesia alters autonomic balance by reducing parasympathetic tone less than sympathetic tone, which may predispose patients to bradycardia during parasympathetic stimulation.
Cite This Study
Deutschman et al. (1994) studied this question.