Structure and Properties of the Cryptophane‐E/CHCl 3 Complex, a Stable van der Waals Molecule

In the absence of hydrophobic effects, the driving force for complexation between neutral host and guest molecules (e.g., cryptophane E and halomethanes) is a function of several factors. If size and form are suitable, as in the CHC13 complex 1, complexation is enthalpy driven, and stable supermolecules result (“van der Waals molecules”).