Key result
Higher baseline A1C values were associated with lower cognitive test scores in ~3,000 patients with type 2 diabetes, potentially mediated by postprandial glucose levels and variation.
Higher baseline A1C is associated with lower cognitive function in patients with type 2 diabetes and cardiovascular risk factors.
No immediate practice change; hypothesis-generating for glycemic variability in cognitive outcomes among type 2 diabetes.
Abbatecola and Paolisso suggest that the association found in the ∼3,000-person cross-sectional analysis of baseline data from the Action to Control Cardiovascular Risk in Diabetes Memory-Memory in Diabetes (ACCORD-MIND) study between higher A1C values and lower cognitive test scores may be mediated at least partially by postprandial glucose levels and its variation index …
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Tali Cukierman‐Yaffe (2009) studied this question. Higher baseline A1C values were associated with lower cognitive test scores in ~3,000 patients with type 2 diabetes, potentially mediated by postprandial glucose levels and variation.
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