What question did this study set out to answer?

To determine whether low-dose bisphenol A exposure during the pubertal window drives mammary gland tumorigenesis through stem cell-mediated alterations.

February 11, 2014Cancer Prevention Research

Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell Function Leading to Early Neoplasia in Regenerated Glands

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To determine whether low-dose bisphenol A exposure during the pubertal window drives mammary gland tumorigenesis through stem cell-mediated alterations.
Exposed 21-day-old Balb/c mice to oral bisphenol A (25 μg/kg/d) by gavage for 3 weeks during puberty, followed by a single oral 7,12-dimethylbenz(a)anthracene (DMBA) challenge (30 mg/kg) at 2 months in a subset of mice.
Isolated primary mammary cells at 6 weeks, 2 months, and 4 months of age to assess mammary stem cell (MaSC) quantification, gland regenerative capacity, and gene expression profiles via deep sequencing of mammospheres.
Pubertal bisphenol A exposure stimulated increased lateral branching and hyperplasia in adult glands, producing an acute rise in MaSCs at 6 weeks and a delayed expansion of luminal progenitors at 4 months.
Mammary stem cells isolated from bisphenol A-exposed mice displayed altered regenerative function, generating early neoplastic lesions comparable to DMBA-induced transformation.
Deep sequencing of MaSC-enriched mammospheres revealed dysregulated gene expression patterns matching signatures found in human breast cancer neoplastic lesions.

Authors

DWDanhan WangWenzhou Medical University HGHui GaoThe University of Texas MD Anderson Cancer Center ABAbhik BandyopadhyayThe University of Texas Health Science Center at Houston

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Implication

Preclinical study reveals pubertal bisphenol A exposure alters mammary stem cell activity in mice, indicating early-life chemical exposure promotes breast cancer risk.

Cite This Study

Wang et al. (2014) studied this question.

synapsesocial.com/papers/6a9926d296b2e868bfe11446 https://doi.org/10.1158/1940-6207.capr-13-0260

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Implication

Preclinical study reveals pubertal bisphenol A exposure alters mammary stem cell activity in mice, indicating early-life chemical exposure promotes breast cancer risk.

Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell Function Leading to Early Neoplasia in Regenerated Glands

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Discussion

Implication

Cite This Study

Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell Function Leading to Early Neoplasia in Regenerated Glands

Key Points

Discussion

Implication

Cite This Study

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