Key result
A higher dose of clopidogrel successfully overcame clopidogrel resistance in a patient who experienced simultaneous thrombosis of two drug-eluting coronary artery stents.
Why the study?
Does a higher dose of clopidogrel overcome clopidogrel resistance in a patient with simultaneous stent thrombosis?
Case Report (n=1)
Does a higher dose of clopidogrel overcome clopidogrel resistance in a patient with simultaneous stent thrombosis?
Platelet function analysis may be useful to guide antiplatelet therapy and overcome clopidogrel resistance in patients with stent thrombosis.
Answers are grounded in this paper and cite their sources.
May support platelet-guided clopidogrel dosing in resistant stent thrombosis; hypothesis-generating and requires prospective validation.
Despite aggressive antiplatelet therapy in the setting of PCI, the incidence of acute stent thrombosis remains approximately 0.5-2%. We report a patient with simultaneous thrombosis of two drug-eluting coronary artery stents, suggesting a systemic thrombotic state. Evaluation by optical platelet aggregometry revealed clopidogrel resistance, which was overcome at a higher drug dose. We aim to highlight the potential utility of platelet function analysis to guide therapy for patients in whom inadequate antiplatelet therapy may have catastrophic clinical outcomes.
No takes yet. Share an insight, caveat, or question.
Lee et al. (2007) conducted a case report in Simultaneous thrombosis of two drug-eluting coronary artery stents and clopidogrel resistance (n=1). Higher clopidogrel dose was evaluated on Overcoming clopidogrel resistance. A higher dose of clopidogrel successfully overcame clopidogrel resistance in a patient who experienced simultaneous thrombosis of two drug-eluting coronary artery stents.
Synapse has enriched 10 related papers. Consider them for comparative context: