Key result
The ABCB1 rs1045642 polymorphism was significantly associated with an increased risk of aspirin resistance (OR 1.5) and clopidogrel resistance in patients with ischemic stroke.
Why the study?
To investigate the association between gene polymorphisms and antiplatelet resistance in patients with ischemic stroke.
Are ABCB1 gene polymorphisms associated with aspirin or clopidogrel resistance in patients with ischemic stroke?
Meta-Analysis (n=4,784)
Are ABCB1 gene polymorphisms associated with aspirin or clopidogrel resistance in patients with ischemic stroke?
The ABCB1 rs1045642 polymorphism is significantly associated with clopidogrel resistance in patients with ischemic stroke.
Answers are grounded in this paper and cite their sources.
May support ABCB1 rs1045642 testing to predict clopidogrel resistance in IS; hypothesis-generating pending prospective validation.
OBJECTIVE: gene polymorphisms and antiplatelet resistance in patients with IS. METHODS: polymorphisms and antiplatelet resistance in patients with IS. All the statistical analyses were performed using STATA version 11.0. RESULTS: rs1045642 polymorphism might be significantly associated with clopidogrel resistance in IS (A. Homozygote model: OR=3.35, 95% CI [1.99, 5.63], P=0.000; B. Heterozygote model: OR=0.81, 95% CI [0.54, 1.21], P=0.895; C. Dominant model: OR=1.41, 95% CI [0.59, 3.36], P=0.435; D. Recessive model: OR=3.43, 95% CI [2.14, 5.51], P=0.000). CONCLUSION: rs1045642 polymorphism and resistance to clopidogrel or aspirin in patients with IS.
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Junjie Lv (2025) conducted a meta-analysis in Ischemic stroke (n=4,784). ABCB1 rs1045642 polymorphism vs. Wild-type/reference genotypes was evaluated on Aspirin resistance in ischemic stroke (Allele model) (OR 1.5, 95% CI 1.10-2.05, p=0.010). The ABCB1 rs1045642 polymorphism was significantly associated with an increased risk of aspirin resistance (OR 1.5) and clopidogrel resistance in patients with ischemic stroke.
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