Key result
Retinal deep learning model detects mild cognitive impairment in CAD patients with ~0.83 AUC.
Why the study?
Does a retinal image-based deep learning model accurately detect mild cognitive impairment in patients with coronary artery disease?
Cross-Sectional (n=4,357)
No
Does a retinal image-based deep learning model accurately detect mild cognitive impairment in patients with coronary artery disease?
A deep learning algorithm using fundus images demonstrated good diagnostic performance for detecting mild cognitive impairment in patients with coronary artery disease, offering a potential non-invasive screening tool.
BACKGROUND: Coronary artery disease (CAD) is linked to an increased risk of mild cognitive impairment (MCI). Effective and convenient screening methods for identifying MCI from the CAD population are still lacking. This study aims to develop a deep learning model using fundus images to optimise MCI diagnosis in the CAD population, achieving early intervention and improving prognosis. METHODS: Patients with CAD (at least one ≥50% stenosis) from July 2021 to July 2023 at Beijing Anzhen Hospital were included in the single-centre cross-sectional study. Eligible patients from July 2021 to May 2023 were randomly assigned in an 8:2 ratio for training and internal testing of the model. Patients enrolled from June 2023 to July 2023 were included in the external validation group. Four different convolutional neural network architectures were used to train the subjects' fundus images. The reference standards were a Mini-Mental State Examination (MMSE) score of <27 and a Montreal Cognitive Assessment (MoCA) score of <26, respectively. A comprehensive visual model of MCI detection was established through model integration. RESULTS: A total of 9009 eligible images from 4357 patients with CAD were collected. The artificial intelligence (AI) algorithm based on the MMSE achieved an area under the curve (AUC) of 0.832 (95% CI 0.800 to 0.863) in the test group and 0.776 (95% CI 0.730 to 0.821) in the validation group. The AI algorithm based on the MoCA achieved an AUC of 0.764 (95% CI 0.742 to 0.785) in the test group and 0.725 (95% CI 0.701 to 0.750) in the validation group. The calibration curves of the internal test sets of the two models exhibited a good calibration effect. The results of decision curves revealed extensive clinical application value. CONCLUSION: The AI algorithm trained on fundus images in this study exerted promising performance in screening MCI in the CAD population and might be a non-invasive and effective alternative for early diagnosis of the disease. TRIAL REGISTRATION NUMBER: NCT06102226.
No takes yet. Share an insight, caveat, or question.
Feng et al. (2025) conducted a cross-sectional in Coronary artery disease (CAD) and mild cognitive impairment (MCI) (n=4,357). Retinal image-based deep learning model vs. Reference standards (MMSE <27 and MoCA <26) was evaluated on Mild cognitive impairment detection (MMSE reference) (AUC 0.832, 95% CI 0.800-0.863). A retinal image-based deep learning model detected mild cognitive impairment in patients with coronary artery disease with an AUC of 0.832 (95% CI 0.800-0.863) against the MMSE reference standard.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: