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June 2, 2025International Journal of Therapy and Rehabilitation

The effects of patient-controlled epidural analgesia on early rehabilitation programmes following total knee replacement surgery: a retrospective cross-sectional study

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Key result

Mobilising on the first day after total knee replacement surgery was associated with significantly higher levels of independence in daily activities compared to mobilising on the second day (P≤0.05).

Why the study?

Although patient-controlled epidural analgesia provides superior analgesia post-surgery, its impact on the efficacy and safety of early rehabilitation after total knee replacement remains understudied.

Does patient-controlled epidural analgesia affect early rehabilitation and functional independence in patients following total knee replacement surgery?

Population

186 patients receiving patient-controlled epidural analgesia after elective unilateral total knee replacement

Comparison

Mobilisation on the first day vs second day following surgery

Design

Retrospective cross-sectional study

Authors

KAKhalid AlzahraniKing Abdulaziz UniversityMLMawaddah Al LuhaybiSecurity Forces HospitalASAbdan Bin SayeedSecurity Forces Hospital

Discussion

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Implication

Early mobilization after total knee replacement was associated with greater independence without increased pain; leaves open effects of patient-controlled epidural analgesia in prospective trials.

Study Design

Type

Cross-Sectional (n=186)

Multicenter

No

Structured PICO

Does patient-controlled epidural analgesia affect early rehabilitation and functional independence in patients following total knee replacement surgery?

P
Population
186 patients (mean age 68.12 years) who received patient-controlled epidural analgesia following elective unilateral total knee replacement surgery.
E
Exposure
Patient-controlled epidural analgesia (PCEA) within a multimodal pain management plan
C
Comparator
Patients who started mobilising on the first day versus those who started mobilising on the second day following surgery
O
Outcome
Impact on early rehabilitation (ambulation start day, independence in daily activities measured by Elderly Mobility Scale and Barthel Index)patient reported

Main Result

p-value: p=≤0.05

Patient-controlled epidural analgesia following total knee replacement surgery does not adversely affect early rehabilitation and facilitates early functional independence.

Cite This Study

Alzahrani et al. (2025) conducted a cross-sectional in total knee replacement surgery (n=186). Mobilising on the first day vs. Mobilising on the second day was evaluated on Levels of independence in daily activities (Elderly Mobility Scale and Barthel Index) (p=≤0.05). Mobilising on the first day after total knee replacement surgery was associated with significantly higher levels of independence in daily activities compared to mobilising on the second day (P≤0.05).

synapsesocial.com/papers/6a9929c813e19562d9f0d55fhttps://doi.org/10.12968/ijtr.2024.0010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.1963 · 12,398 citations
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  3. 3Early Neuromuscular Electrical Stimulation to Optimize Quadriceps Muscle function Following Total Knee Arthroplasty: A Case Report2007 · 66 citations
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