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Utilizing the recently reported compound, 1‐methyl‐5‐(trifluoromethyl)‐2,3,4,5‐tetrahydropyrazol‐3‐one, 4, a series of regional isomers of 1‐methyl‐5‐(trifluoromethyl)‐3‐chloropyrazole, newly substituted in the 4‐position were prepared by original syntheses. Chief among them was the new regional 4‐hydroxy isomer, 3a, a linkage reagent valuable for preparing new SAR candidates in the bio‐active pyrazole phenyl ether series.
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John P. Chupp (1994) studied this question.
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