Answers are grounded in this paper and cite their sources.
The potential significance of the phosphorylation of SV40 large T antigen for oligomers and complexes with the cellular protein p53 was investigated. We observed that T antigen oligomers remain stable after enzymatic dephosphorylation by alkaline phosphatase up to 80%. Separate analysis of free and p53-bound T antigen revealed a considerably lower phosphorylation of the p53-bound subclass. Therefore, a simple correlation between the overall phosphorylation of T antigen and the formation of oligomers and T-p53 complexes is highly unlikely.
No takes yet. Share an insight, caveat, or question.
Stürzbecher et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: