Why the study?
Does gemfibrozil improve fibrinolytic function in men with combined hyperlipoproteinemia?
Population
21 men with combined hyperlipoproteinemia and elevated plasminogen activator inhibitor-1 activity at rest
Comparison
Gemfibrozil vs Placebo (crossover design)
Design
RCT, crossover study, double-blind
Authors
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Gemfibrozil's triglyceride reduction does not improve fibrinolytic markers; challenges fibrinolysis as a mediator of its cardiovascular effects.
Does gemfibrozil improve fibrinolytic function in men with combined hyperlipoproteinemia?
Gemfibrozil significantly improves lipid profiles in men with combined hyperlipoproteinemia but does not improve fibrinolytic function, suggesting its primary preventive effect is not mediated through improved fibrinolysis.
Bröijersén et al. (1996) studied this question.
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