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September 3, 2026Hypertension in PregnancyOpen Access

Hypertensive disorders during pregnancy and cognitive outcomes in children: the ALSPAC study

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Authors

BDBerihun DachewCurtin UniversityGAGetinet AyanoCurtin UniversityRARosa AlatiThe University of Queensland

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Implication

Prospective cohort study reveals no link between maternal hypertension during pregnancy and lower IQ in offspring, indicating no adverse long-term cognitive effects.

Key Points

  • To examine whether hypertensive disorders during pregnancy are associated with offspring intelligence quotient (IQ) at ages 8 and 16 years.
  • Analyzed data from the UK-based Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, evaluating mother–child pairs at age 8 (N>4,900) and age 16 (N>3,300).
  • Assessed offspring IQ using a shortened Wechsler Intelligence Scale for Children (WISC-III) at age 8 and the Wechsler Abbreviated Scale of Intelligence (WASI) at age 16 via binary and multinomial logistic regression models.
  • Hypertensive disorders of pregnancy were not associated with lower offspring IQ at either age 8 or age 16.
  • Gestational hypertension, but not pre-eclampsia, was associated with higher odds of above-average IQ compared to average IQ at age 16 in multinomial models, but this finding did not appear at age 8 and was not replicated across IQ tertiles.

Cite This Study

Dachew et al. (2026) studied this question.

synapsesocial.com/papers/6a9934b4636c6408cfa7c7a2https://doi.org/10.1080/10641955.2026.2725449
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ALSPAC–The Avon Longitudinal Study of Parents and Children2001 · 1,587 citations
  2. 2Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study2024 · 12 citations
  3. 3Maternal hypertension and neurodevelopmental outcome in very preterm infants1998 · 89 citations
  4. 4Infant sex, obstetric risk factors, and 2‐year neurodevelopmental outcome among preterm infants2009 · 79 citations
  5. 5Early life predictors of childhood intelligence: evidence from the Aberdeen children of the 1950s study2005 · 96 citations