What does this research mean for the field?

A low preoperative platelet-to-lymphocyte ratio is an independent predictor of early augmented renal clearance in patients undergoing intracerebral hemorrhage surgery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate whether the preoperative platelet-to-lymphocyte ratio can serve as an independent predictive biomarker for augmented renal clearance in patients undergoing intracerebral hemorrhage surgery.

September 3, 2026Clinical Nephrology

Role of platelet-to-lymphocyte ratio in predicting augmented renal clearance following intracerebral hemorrhage surgery

View Full Paper

Ask AI

Bookmark

Authors

JDJiaxin DongAlbert Einstein College of Medicine QZQian Zhang MHMin Huang

Discussion

Member takes

Implication

Retrospective cohort study finds low platelet-to-lymphocyte ratio predicts augmented renal clearance after brain hemorrhage surgery, indicating improved risk stratification for drug dosing.

Key Points

To investigate whether the preoperative platelet-to-lymphocyte ratio can serve as an independent predictive biomarker for augmented renal clearance in patients undergoing intracerebral hemorrhage surgery.
Conducted a single-center retrospective cohort study of 174 patients who underwent surgery for intracerebral hemorrhage.
Used Pearson or Spearman correlation, restricted cubic splines, and multivariable logistic regression to analyze associations between platelet-to-lymphocyte ratio and augmented renal clearance.
Assessed predictive accuracy and clinical utility using receiver operating characteristic curve analysis and category net reclassification improvement.
Identified low preoperative platelet-to-lymphocyte ratio as an independent predictor of early augmented renal clearance, alongside an APACHE II score of 10–20 and hemorrhage volume ≤ 30 mL.
Incorporating platelet-to-lymphocyte ratio into a composite clinical model (APACHE II, SOFA, and GCS) improved the AUC from 0.70 (95% CI: 0.62–0.78) to 0.73 (95% CI: 0.65–0.81).
Adding the ratio to the composite scoring system resulted in a category net reclassification improvement of 0.12 (95% CI: 0.00–0.25).

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/6a9934cf636c6408cfa7c8e6 https://doi.org/10.5414/cn111993

View Full Paper

Ask AI

Bookmark

Implication

Retrospective cohort study finds low platelet-to-lymphocyte ratio predicts augmented renal clearance after brain hemorrhage surgery, indicating improved risk stratification for drug dosing.

Role of platelet-to-lymphocyte ratio in predicting augmented renal clearance following intracerebral hemorrhage surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

Role of platelet-to-lymphocyte ratio in predicting augmented renal clearance following intracerebral hemorrhage surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider