What question did this study set out to answer?

To evaluate the association between preoperative platelet-to-lymphocyte ratio (PLR) and post-hepatectomy hemorrhage (PHH), and to establish an exploratory predictive cutoff.

September 17, 2026European journal of medical researchOpen Access

Preoperative platelet-to-lymphocyte ratio and post-hepatectomy hemorrhage risk after elective hepatectomy: a single-center cohort study with exploratory calendar-time assessment of a candidate cutoff

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Authors

魏魏克茂Sichuan University HQHaizhou QiuSichuan University QRQiuping RenSichuan University

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Implication

Cohort study finds lower preoperative platelet-to-lymphocyte ratio tracks with post-hepatectomy hemorrhage in elective liver surgery, suggesting utility alongside standard clinical variables.

Key Points

To evaluate the association between preoperative platelet-to-lymphocyte ratio (PLR) and post-hepatectomy hemorrhage (PHH), and to establish an exploratory predictive cutoff.
Analyzed N=4,386 adult patients undergoing elective hepatectomy from a single-center cohort between 2022 and 2024, divided into a 2022–2023 threshold derivation cohort and a 2024 internal temporal validation cohort.
Calculated PLR from routine complete blood counts obtained within 7 days preoperatively and assessed 30-day ISGLS-defined PHH using documented bleeding and a fixed postoperative hemoglobin baseline.
Post-hepatectomy hemorrhage occurred in 233 of 4,386 patients (5.3%), including 121 grade B/C bleeding events (2.8%).
Each 25-unit decrement in continuous PLR independently associated with higher PHH risk (adjusted OR 1.10, 95% CI 1.06–1.14; p < 0.001), showing continuous AUCs of 0.664 in derivation and 0.647 in temporal testing.
A derived cutoff of PLR ≤125 independently predicted any PHH (adjusted OR 1.88, 95% CI 1.44–2.46; p < 0.001) and grade B/C PHH (adjusted OR 1.76, 95% CI 1.24–2.50; p = 0.002), separating groups with 8.9% versus 3.8% PHH incidence despite a low positive predictive value (8.9%).

Cite This Study

魏克茂 et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6c75f706d05830e5585 https://doi.org/10.1186/s40001-026-05111-3

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Implication

Cohort study finds lower preoperative platelet-to-lymphocyte ratio tracks with post-hepatectomy hemorrhage in elective liver surgery, suggesting utility alongside standard clinical variables.

Preoperative platelet-to-lymphocyte ratio and post-hepatectomy hemorrhage risk after elective hepatectomy: a single-center cohort study with exploratory calendar-time assessment of a candidate cutoff

Discussion

Member takes

Implication

Key Points

Cite This Study

Preoperative platelet-to-lymphocyte ratio and post-hepatectomy hemorrhage risk after elective hepatectomy: a single-center cohort study with exploratory calendar-time assessment of a candidate cutoff

Discussion

Member takes

Implication

Key Points

Cite This Study

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