Predictive value of platelet distribution width, neutrophil-to-lymphocyte ratio, and alanine aminotransferase for recurrence of pregnancy loss in early gestation
Retrospective case-control study reveals elevated PDW, NLR, and ALT predict miscarriage recurrence in early pregnancy, highlighting a simple combined biomarker panel for risk stratification.
Key Points
To evaluate whether combining platelet distribution width, neutrophil-to-lymphocyte ratio, and alanine aminotransferase can effectively predict the recurrence of early pregnancy loss.
Conducted a retrospective case-control study of 305 patients with early recurrent pregnancy loss between January 2024 and May 2025.
Compared peripheral blood platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), alanine aminotransferase (ALT), and other routine laboratory values between a pregnancy loss group (n=116) and a live birth group (n=189).
Identified independent predictors using multivariate logistic regression and evaluated discrimination using receiver operating characteristic (ROC) analysis.
Peripheral blood PDW, NLR, and ALT levels were significantly higher among patients in the pregnancy loss group than in the live birth group.
Multivariate logistic regression confirmed that PDW, NLR, and ALT were independent risk factors for recurrent pregnancy loss.
The combined three-marker model yielded an area under the receiver operating characteristic curve of 0.706, demonstrating superior predictive performance over any individual biomarker.