Thio- β -D-glucosides: Synthesis and Evaluation as Glycosidase Inhibitors and Activators

Structurally simple 1-thio- β -D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens . Significant selective inhibition was observed for α - and β -glucosidases, while a weak to moderate activation for α - and β -galactosidases.