What does this research mean for the field?

There is currently little evidence for a consistent association between social cognition impairments and social behavior in patients with neurodegenerative diseases, challenging the assumption that these impairments directly underlie behavioral changes. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To systematically evaluate the relationship between performance-based measures of social cognition and proxy ratings of social behavior across neurodegenerative diseases.

September 3, 2026Neuropsychology ReviewOpen Access

The Relationship Between Social Cognition and Social Behavior in Patients with a Neurodegenerative Disease: A Systematic Review and Meta-Analysis

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Authors

FGFloor Gelmers ASA. E. Straatsma HKHenk A. L. Kiers

Discussion

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Overview

Systematic review and meta-analysis finds weak associations between social cognition and social behavior in neurodegenerative disease, suggesting current tests poorly reflect daily conduct.

Key Points

To systematically evaluate the relationship between performance-based measures of social cognition and proxy ratings of social behavior across neurodegenerative diseases.
Conducted a systematic literature search in PubMed and PsycINFO from inception up to September 5th, 2023.
Analyzed 21 studies that assessed the correlation between performance-based social cognition tasks and proxy-reported behavioral symptoms in patients with neurodegenerative diseases.
Identified weak associations between better emotion recognition and fewer overall behavioral symptoms (r = -0.23, 95% CI [-0.42, -0.02]) and lower apathy (r = -0.24, 95% CI [-0.46, 0.01]).
Disinhibition was more frequently linked to social cognition than agitation or irritability, and affective theory of mind correlated more often with social behavior than cognitive theory of mind.

Cite This Study

Gelmers et al. (2026) studied this question.

synapsesocial.com/papers/6a99352e636c6408cfa7d2d7 https://doi.org/10.1007/s11065-026-09700-1

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September 3, 2026Neuropsychology ReviewOpen Access

The Relationship Between Social Cognition and Social Behavior in Patients with a Neurodegenerative Disease: A Systematic Review and Meta-Analysis

View Full Paper

Ask AI

Bookmark

Authors

FGFloor Gelmers ASA. E. Straatsma HKHenk A. L. Kiers

Discussion

Member takes

Overview

Systematic review and meta-analysis finds weak associations between social cognition and social behavior in neurodegenerative disease, suggesting current tests poorly reflect daily conduct.

Key Points

To systematically evaluate the relationship between performance-based measures of social cognition and proxy ratings of social behavior across neurodegenerative diseases.
Conducted a systematic literature search in PubMed and PsycINFO from inception up to September 5th, 2023.
Analyzed 21 studies that assessed the correlation between performance-based social cognition tasks and proxy-reported behavioral symptoms in patients with neurodegenerative diseases.
Identified weak associations between better emotion recognition and fewer overall behavioral symptoms (r = -0.23, 95% CI [-0.42, -0.02]) and lower apathy (r = -0.24, 95% CI [-0.46, 0.01]).
Disinhibition was more frequently linked to social cognition than agitation or irritability, and affective theory of mind correlated more often with social behavior than cognitive theory of mind.

Cite This Study

Gelmers et al. (2026) studied this question.

synapsesocial.com/papers/6a99352e636c6408cfa7d2d7 https://doi.org/10.1007/s11065-026-09700-1

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