In vitro study reveals sinapine prevents oxidative damage and restores myogenic differentiation in C2C12 muscle cells, suggesting therapeutic potential for muscle health.
Myogenesis is an essential process in skeletal muscle development and regeneration. However, it is often suppressed by oxidative stress. The objective of this study was to investigate the effects of tert-butyl hydroperoxide (TBHP) on C2C12 myogenic differentiation and the protective effect of sinapine. TBHP impaired differentiation without affecting cell viability. Pretreatment with sinapine attenuated the TBHP-induced impairment dose-dependently up to 100 μM. Furthermore, sinapine restored the reduced expression of myogenic regulators, including PAX7, MyoD, and Myogenin. These results suggest that sinapine protects against oxidative stress-induced myogenic impairment and may serve as a potential functional compound for muscle health.
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Kang et al. (2026) studied this question.
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