What does this research mean for the field?

Extended cholecystectomy is associated with improved overall survival compared to simple cholecystectomy in patients with pathologic T1b gallbladder cancer, but does not significantly improve disease-specific survival or recurrence rates. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare oncologic outcomes, including survival and recurrence rates, between extended cholecystectomy and simple cholecystectomy in patients with pathologically confirmed T1b gallbladder cancer.

September 3, 2026Annals of Hepato-Biliary-Pancreatic SurgeryOpen Access

Extended versus simple cholecystectomy for pathologic T1b gallbladder cancer: A systematic review and meta-analysis

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To compare oncologic outcomes, including survival and recurrence rates, between extended cholecystectomy and simple cholecystectomy in patients with pathologically confirmed T1b gallbladder cancer.
Systematic search of MEDLINE, Embase, and Cochrane databases through July 2025 (PROSPERO CRD42024498316).
Analyzed 26 non-randomized comparative cohort studies encompassing 1,316 patients, evaluated for risk of bias using the ROBINS-I tool.
Pooled hazard ratios (HR) and risk ratios (RR) with 95% confidence intervals using fixed- or random-effects models.
Extended cholecystectomy demonstrated a significant improvement in 5-year overall survival compared with simple cholecystectomy (HR 0.48; 95% CI 0.33–0.70; p = 0.0001; I² = 53%).
No statistically significant difference emerged for 5-year disease-specific survival (HR 0.73; 95% CI 0.41–1.28; p = 0.27) or recurrence-free survival (RR 0.75; 95% CI 0.57–1.00; p = 0.0504).

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Implication

Systematic review and meta-analysis finds extended cholecystectomy improves overall survival in pT1b gallbladder cancer, suggesting the potential value of risk-adapted surgery.

Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/6a99352e636c6408cfa7d34c https://doi.org/10.14701/ahbps.26-091

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Implication

Systematic review and meta-analysis finds extended cholecystectomy improves overall survival in pT1b gallbladder cancer, suggesting the potential value of risk-adapted surgery.

Extended versus simple cholecystectomy for pathologic T1b gallbladder cancer: A systematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study

Extended versus simple cholecystectomy for pathologic T1b gallbladder cancer: A systematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study

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