Biological Pathways of Strength Preservation During Calorie Restriction‐Induced Weight Loss Among Adults Without Obesity
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Implication
Randomized trial reveals muscle gene pathways linked to strength retention during calorie restriction in adults without obesity, indicating targets to prevent functional decline.
Key Points
- To identify molecular predictors and biological pathways associated with the preservation of muscular strength during calorie restriction-induced weight loss.
- Secondary analysis of the CALERIE trial (NCT00427194), a 2-year randomized controlled trial testing caloric restriction versus ad libitum intake in healthy adults without obesity.
- Tracked whole-body mass and knee extensor strength over 12 months, paired with transcriptomic profiling of skeletal muscle biopsies in a subset (N=42).
- Modeled associations between changes in muscle gene expression and changes in strength while adjusting for whole-body mass changes.
- Identified 151 genes significantly associated with knee extensor strength changes after adjusting for whole-body mass change in the 42-participant subset, prominently including HSP90AA1 and EIF3A.
- Biological pathway analysis demonstrated significant enrichment of pathways governing cellular proliferation, immune regulation, and protein secretion linked to strength retention.
Cite This Study
Moore et al. (2026) studied this question.