Erythema Nodosum‐Like Sarcoidosis With Edematous Swelling of Both Lower Legs and Peripheral Eosinophilia

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Sarcoidosis can present atypically with erythema nodosum-like lesions, edematous swelling of the lower legs, and peripheral eosinophilia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Nobuyuki Kikuchi; Toshiyuki Yamamoto

doi:10.1111/1346-8138.70483

August 31, 2026The Journal of DermatologyOpen Access

Erythema Nodosum‐Like Sarcoidosis With Edematous Swelling of Both Lower Legs and Peripheral Eosinophilia

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Key Points

To describe an atypical clinical presentation of sarcoidosis presenting with erythema nodosum-like cutaneous lesions, edematous swelling of both lower legs, and peripheral eosinophilia.
Clinical evaluation of a patient presenting with bilateral lower leg swelling, erythema nodosum-like lesions, and elevated peripheral eosinophil counts.
Identified sarcoidosis manifesting with lower extremity edematous swelling resembling erythema nodosum in the presence of peripheral eosinophilia.

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Implication

Case report reveals erythema nodosum-like sarcoidosis with bilateral lower leg edema and eosinophilia, highlighting an atypical clinical presentation.

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Kikuchi et al. (2026) studied this question.

synapsesocial.com/papers/6a99353a636c6408cfa7d533 https://doi.org/10.1111/1346-8138.70483

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Erythema Nodosum‐Like Sarcoidosis With Edematous Swelling of Both Lower Legs and Peripheral Eosinophilia

Key Points

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Erythema Nodosum‐Like Sarcoidosis With Edematous Swelling of Both Lower Legs and Peripheral Eosinophilia

Key Points

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Implication

Abstract

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