Rethinking ethanol separation in continuous spirit production from a process intensification perspective

Continuous neutral‐alcohol and food‐grade ethanol production is an energy‐intensive process in which distillation and rectification alone account for 50–85% of total plant energy use. While significant advances in separation technology have emerged over the past two decades, the spirits industry continues to rely predominantly on multi‐effect distillation configurations developed decades ago. This perspective paper evaluates intensified separation technologies for large‐scale continuous production of food‐grade ethanol. Special emphasis is on practical applicability within the constraints of spirit manufacturing, namely food‐grade compatibility, congener management and retrofit feasibility. The ethanol–water azeotrope at 95.63 wt% (96.47 vol%) at atmospheric pressure remains the key thermodynamic challenge, though only for the high‐strength distillate/neutral‐alcohol stage as most finished spirits (bottled at ca 40 vol%) never approach it. Breaking or avoiding it without using (food‐grade‐incompatible) mass separating agents requires an actual rethinking of process design. Technologies are assessed against a technology readiness level (TRL) framework. Cyclic distillation and heat pump‐assisted distillation are identified as near‐term, deployment‐ready solutions offering 30–70% energy savings at TRL 7–9. HIDiC, suitable for new plant designs, can reach up to 77% savings. Hybrid distillation–membrane separation is the most promising medium‐term pathway combining high purity and low energy demand. Pass‐through distillation emerges as a disruptive option enabling concurrent fermentation and alcohol recovery. A decision framework linking feed concentration, target purity, plant scale and capital constraints is proposed to guide technology selection for both new plants and retrofit applications. The findings highlight that the spirits sector is well positioned to reduce its carbon footprint and operating costs by adopting proven process intensification technologies that have demonstrated industrial viability in other sectors.