What does this research mean for the field?

Serum FGF19 levels are decreased in patients with type 2 diabetes compared to healthy controls, but among those with type 2 diabetes, FGF19 levels are relatively elevated in patients with diabetic kidney disease and independently correlate with higher UACR and lower eGFR. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the relationship between circulating fibroblast growth factor 19 (FGF19) levels and diabetic kidney disease assessed by eGFR and UACR in patients with type 2 diabetes.

September 3, 2026Endocrine ResearchOpen Access

Association of serum fibroblast growth factor 19 with DKD as assessed by the UACR and eGFR in patients with type 2 diabetes

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To evaluate the relationship between circulating fibroblast growth factor 19 (FGF19) levels and diabetic kidney disease assessed by eGFR and UACR in patients with type 2 diabetes.
Conducted a cross-sectional study of 330 inpatients with type 2 diabetes and 60 healthy normal controls.
Measured serum FGF19 levels via ELISA and determined renal function using the CKD-EPI eGFR equation and urinary albumin-to-creatinine ratio (UACR).
Analyzed associations using Spearman's correlation, multivariable linear regression adjusting for confounders, and restricted cubic spline models.
Serum FGF19 levels were lower in type 2 diabetes patients than controls (110.25 vs. 242.06 pg/mL, p < 0.001), but among diabetics, levels were significantly higher in those with diabetic kidney disease than those without (122.61 vs. 106.97 pg/mL, p = 0.023).
In fully adjusted multivariable linear regression, serum FGF19 remained independently associated with higher UACR (β = 0.203, t = 2.286, p = 0.024) and lower eGFR (β = -0.170, t = -2.542, p = 0.012).
Restricted cubic spline models confirmed linear relationships between lnFGF19 and both lnUACR (p = 0.480) and eGFR (p = 0.162).

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Implication

Cross-sectional study finds higher serum FGF19 linked to reduced kidney function in type 2 diabetes, suggesting a role for this hormone in diabetic kidney pathology.

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/6a99355b636c6408cfa7d7a2 https://doi.org/10.1080/07435800.2026.2727501

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Implication

Cross-sectional study finds higher serum FGF19 linked to reduced kidney function in type 2 diabetes, suggesting a role for this hormone in diabetic kidney pathology.

Association of serum fibroblast growth factor 19 with DKD as assessed by the UACR and eGFR in patients with type 2 diabetes

Key Points

Discussion

Implication

Cite This Study

Association of serum fibroblast growth factor 19 with DKD as assessed by the UACR and eGFR in patients with type 2 diabetes

Key Points

Discussion

Implication

Cite This Study

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