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September 3, 2026Journal of Public Health and Primary CareOpen Access

Clinical Examination and Scoring Systems in Diabetic Peripheral Neuropathy: A Narrative Review

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Authors

SDSuchitra DubeSHSandipM HulkeSWSantosh Wakode

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Overview

Narrative review demonstrates bedside exams and scoring systems correlate with electrophysiology in diabetic peripheral neuropathy, highlighting practical screening options.

Key Points

  • Synthesize Indian and international literature on the prevalence, pathophysiology, clinical features, and diagnostic utility of bedside examination tools and scoring systems for diabetic peripheral neuropathy.
  • Narrative review synthesizing findings from peer-reviewed articles, clinical trials, and clinical guidelines.
  • Evaluated prevalence data across Indian regions alongside diagnostic utility of clinical examination, validated scoring tools, and reference-standard electrophysiological tests.
  • Reported prevalence of diabetic peripheral neuropathy in India ranges between 19% and 32% across southern, northern, and eastern regions.
  • Bedside assessments—including monofilament testing, vibration sense, ankle reflexes, and pinprick sensation—paired with validated scoring systems (MNSI, DNS, DNE, COMPASS-31) show moderate-to-strong qualitative correlation with nerve conduction studies and autonomic function testing.
  • Advanced diagnostics, such as corneal confocal microscopy and skin biopsy, remain largely impractical for routine frontline screening due to cost and limited availability.

Cite This Study

Dube et al. (2026) studied this question.

synapsesocial.com/papers/6a99355b636c6408cfa7d903https://doi.org/10.4103/jphpc.jphpc_42_25
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  1. 1Clinical Examination Versus Nerve Conduction and Autonomic Function Tests for Diagnosing Diabetic Peripheral Neuropathy2025
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  3. 3Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy Among Outpatient Attendees of Follow-Up Care for Diabetes in Central India2025
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