What question did this study set out to answer?

To evaluate the discriminative ability of the Diabetic Neuropathy Symptom (DNS) and Diabetic Neuropathy Examination (DNE) scores for detecting diabetic polyneuropathy and assess their relationship with autonomic and electrodiagnostic testing.

March 1, 2003Diabetes Care

Clinical Diagnosis of Diabetic Polyneuropathy With the Diabetic Neuropathy Symptom and Diabetic Neuropathy Examination Scores

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Why the study?

Do the DNS and DNE scores accurately diagnose diabetic polyneuropathy and correlate with cardiovascular autonomic function testing and electro-diagnostic studies in diabetic patients?

Population

69 subjects, matched for age and sex

Comparison

Diabetic Neuropathy Symptom and Diabetic… vs Cardiovascular autonomic function testing and…

Design

Case-control

Authors

JMJan-Willem G. MeijerUniversity Medical Center EBEelke BosmaMartini Ziekenhuis JLJ. D. LefrandtOslo University Hospital

Discussion

Member takes

Implication

May aid neuropathy screening in diabetes care; supports validity via objective correlations yet leaves open prospective validation.

Key Points

To evaluate the discriminative ability of the Diabetic Neuropathy Symptom (DNS) and Diabetic Neuropathy Examination (DNE) scores for detecting diabetic polyneuropathy and assess their relationship with autonomic and electrodiagnostic testing.
Evaluated 69 age- and sex-matched participants divided into three groups: diabetic patients with neuropathic foot ulcers (n=24), diabetic patients without neuropathy (n=24), and non-diabetic controls (n=21).
Assessed DNS and DNE scores alongside cardiovascular autonomic function testing (heart rate variability [HRV], baroreflex sensitivity [BRS]) and electrodiagnostic studies (nerve conduction sum [NCS] score, muscle fiber conduction velocity ratio).
Both DNS and DNE scores significantly discriminated diabetic patients with foot ulcers from diabetic controls (P < 0.001), while DNE also distinguished diabetic controls from healthy subjects (P < 0.05).
DNS and DNE scores correlated significantly with electrodiagnostic testing (NCS: r = 0.51 and 0.62; conduction velocity ratio: r = 0.44 and 0.62) and autonomic testing (HRV: r = -0.42 and -0.44; BRS: r = -0.30 and -0.29).
Abnormal DNS and DNE scores were strongly linked to impaired electrodiagnostics (NCS OR 5.6 and 16.8; conduction velocity ratio OR 7.2 and 18.8) and autonomic deficits (HRV OR 4.4 and 5.7; BRS OR 20.7 and 14.2).

Structured PICO

Do the DNS and DNE scores accurately diagnose diabetic polyneuropathy and correlate with cardiovascular autonomic function testing and electro-diagnostic studies in diabetic patients?

Population

69 subjects (24 diabetic patients with neuropathic foot ulcers, 24 diabetic patients without clinical neuropathy or ulcers, and 21 control subjects without diabetes), matched for age and sex

Intervention

Diabetic Neuropathy Symptom (DNS) and Diabetic Neuropathy Examination (DNE) scores

Comparator

Cardiovascular autonomic function testing (cAFT) and electro-diagnostic studies (EDS)

Outcome

Discriminative power for diagnosing diabetic polyneuropathy and correlation with cAFT and EDSsurrogate

The DNS and DNE scores are valid clinical tools for diagnosing diabetic polyneuropathy, correlating well with objective autonomic and electro-diagnostic testing.

Cite This Study

Meijer et al. (2003) studied this question.

synapsesocial.com/papers/6a7d67f32935e92dbc77682d https://doi.org/10.2337/diacare.26.3.697

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Clinical Diagnosis of Diabetic Polyneuropathy With the Diabetic Neuropathy Symptom and Diabetic Neuropathy Examination Scores

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Clinical Diagnosis of Diabetic Polyneuropathy With the Diabetic Neuropathy Symptom and Diabetic Neuropathy Examination Scores

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider