Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings

Q: What does this research mean for the field?

PAMK, a complex heterogeneous glycan, protects against cyclophosphamide-induced thymic necroptosis in goslings by upregulating novel-miR-2 and suppressing the TRADD/MLKL signaling axis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Wanyan Li; Baili Lu; Xiangying Zhou; Shirou Pan; Junhao Wei; Bingxin Li; Nan Cao; Yunmao Huang; Wenjun Liu; Xinliang Fu; Yunbo Tian; Danning Xu

doi:10.1080/01652176.2026.2695104

September 1, 2026Veterinary QuarterlyOpen Access

Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings

View Full Paper

Ask AI

Bookmark

Share

Key Points

To determine the structural composition of PAMK glycans and examine how they protect goslings against cyclophosphamide-induced thymic necroptosis.
Characterized the monosaccharide composition, glycosidic linkages, and branching patterns of PAMK glycans.
Established an in vivo cyclophosphamide (CTX)-induced thymic necroptosis model in goslings with and without dietary PAMK supplementation.
Evaluated cytokine profiles, oxidative stress, and the regulatory interactions between novel-miR-2 and the necroptosis mediators TRADD and MLKL.
Structural analysis identified PAMK as a complex, highly branched glycan predominantly composed of arabinose, galactose, rhamnose, galacturonic acid, and glucose.
Dietary PAMK restored cytokine homeostasis and suppressed CTX-induced necroptosis pathway activation by upregulating novel-miR-2 expression.
Functional modulation confirmed that novel-miR-2 directly repressed TRADD and MLKL expression, attenuating downstream necroptotic death and oxidative stress.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Experimental study reveals that dietary PAMK suppresses cyclophosphamide-induced thymic necroptosis in goslings, highlighting its promise as an immunoregulatory agent in poultry.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a993576636c6408cfa7da27 https://doi.org/10.1080/01652176.2026.2695104

View Full Paper

Ask AI

Bookmark

Share

Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Structural characterization of PAMK and its protective effect against thymic necroptosis in goslings

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading