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Mechanistic study reveals STIM1-ORAI-mediated calcium entry reinforces capillary-to-arteriole signaling during neural stimulation, highlighting a critical driver of functional hyperemia.
Neurovascular coupling ensures that active neuronal circuits receive the blood supply needed to sustain brain function. In this issue of Science Signaling , Lavanderos et al. identify STIM1-ORAI–mediated Ca 2+ entry as a mechanism that reinforces capillary-to-arteriole communication, sustaining functional hyperemia during repetitive neuronal stimulation.
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Fabrice Dabertrand (2026) studied this question.
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