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September 3, 2026Cell Biology InternationalOpen Access

Insights Into Aggregation‐Delayed Phenotype of Dictyostelium discoideum

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Authors

SASarah Abdulaziz AlamerKing Faisal University

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Implication

Review examines signaling regulators of delayed aggregation in Dictyostelium discoideum, highlighting the mechanistic role of divalent cations.

Key Points

  • To review the signaling mechanisms responsible for the aggregation-delayed phenotype in Dictyostelium discoideum, focusing on regulatory factors beyond the canonical aggregation cascade.
  • Synthesized findings on Dictyostelium discoideum transition mechanisms from vegetative feeding to starvation-induced multicellular aggregation.
  • Evaluated the roles of heterotrimeric G protein pathways, cyclic AMP signaling, and natural products in altering aggregation timelines.
  • Disruption of heterotrimeric G protein signaling and its downstream targets blocks aggregation entirely, causing an aggregation-minus phenotype.
  • Exposure to specific natural products induces an aggregation-delayed phenotype rather than complete arrest, with evidence pointing to divalent cations as critical underlying regulators.

Cite This Study

Sarah Abdulaziz Alamer (2026) studied this question.

synapsesocial.com/papers/6a993586636c6408cfa7dce8https://doi.org/10.1002/cbin.70204
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