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September 3, 2026Journal of Korean Academy of Fundamentals of NursingOpen Access

Factors Influencing Quality of Life in Pancreatic Cancer Patients Undergoing Home-Based Chemotherapy via Disposable Infusion Pumps

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Authors

HKhyesun KimIHIlseon HwangMKMiyeong Kim

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Overview

Cross-sectional study reveals determinants of quality of life in pancreatic cancer patients on home-based FOLFIRINOX, highlighting the importance of functional status, self-efficacy, and nutrition.

Key Points

  • To assess the quality of life and determine its influencing factors in patients with pancreatic cancer receiving home-based FOLFIRINOX chemotherapy via disposable infusion pumps.
  • Conducted a descriptive cross-sectional study of 111 adults with pancreatic cancer receiving FOLFIRINOX with 46-hour ambulatory 5-fluorouracil infusions at a tertiary hospital.
  • Collected data using electronic medical records and validated self-report instruments, including the EORTC QLQ-C30, Self-Efficacy for Managing Chronic Disease Scale, a modified self-care performance tool, and psychological symptom inventories.
  • Evaluated relationships using descriptive statistics, t-tests, ANOVA, Pearson correlation coefficients, and multivariable linear regression analysis.
  • The mean quality of life score was 59.99 (SD=21.87), which positively correlated with functional status (r=0.59, p<0.001) and self-efficacy (r=0.50, p<0.001), and negatively correlated with symptom burden (r=-0.56, p<0.001).
  • The multivariable regression model was statistically significant (F=13.56, p<0.001) and accounted for 40.7% of the total variance in quality of life.
  • Significant independent predictors of quality of life included higher functional status (β=0.40, p=0.002), higher self-efficacy (β=0.24, p=0.009), and appetite loss (β=-0.20, p=0.041).

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a993592636c6408cfa7dd94https://doi.org/10.7739/jkafn.2026.33.3.334
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