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September 3, 2026JACC AsiaOpen Access

Combined LV and RV dysfunction in aortic stenosis carries uncertain prognostic significance after TAVR.

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Why the study?

Outcomes after TAVR reflect cumulative myocardial injury beyond stenosis, and the prognostic significance of coexisting left and right ventricular dysfunction in aortic stenosis remains uncertain.

Follow-up

1-Year

Key result

Combined left and right ventricular dysfunction presents as overlapping but distinct functional profiles in aortic stenosis, with uncertain prognostic significance after TAVR.

Authors

YLYingqi LiuZGZhenyi GeZGZhenyi Ge

Discussion

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Overview

Biventricular dysfunction may refine post-TAVR risk stratification; leaves open whether myocardial-targeted therapies improve outcomes beyond valve replacement.

Key Points

  • To assess the prognostic significance and 1-year clinical outcomes associated with coexisting left and right ventricular dysfunction in patients undergoing transcatheter aortic valve replacement.
  • Characterized functional left ventricular (LV) and right ventricular (RV) dysfunction profiles in patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis.
  • Tracked post-procedural clinical outcomes to assess the cumulative impact of biventricular myocardial impairment across 1 year of follow-up.
  • Left and right ventricular dysfunction manifest as distinct yet overlapping functional profiles in patients with severe aortic stenosis.
  • Post-TAVR outcomes reflect cumulative, underlying myocardial injury that extends beyond the relief of primary valvular stenosis.

Cite This Study

Liu et al. (2026) studied this question. Combined left and right ventricular dysfunction presents as overlapping but distinct functional profiles in aortic stenosis, with uncertain prognostic significance after TAVR.

synapsesocial.com/papers/6a9935b1636c6408cfa7e1cdhttps://doi.org/10.1016/j.jacasi.2026.07.015
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