What does this research mean for the field?

A newly developed high-performance liquid chromatography method integrating analytical quality by design and green analytical chemistry metrics provides accurate, precise, and eco-friendly simultaneous quantification of pravastatin, rosuvastatin, atorvastatin, and fenofibrate. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and validate an analytical quality by design-driven, eco-friendly HPLC method for simultaneously quantifying pravastatin, rosuvastatin, atorvastatin, and fenofibrate in bulk and solid dosage forms.

September 3, 2026Separation Science PlusOpen Access

Multicomponent Analysis of Antihyperlipidemic Drugs: Integrating Analytical Quality by Design and Multi‐Metric Green Liquid Chromatography

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Authors

BBukkapatnamGITAM University RSRaja SundararajanAndhra University

Discussion

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Implication

Methodological study demonstrates rapid, sustainable chromatographic separation of statins and fenofibrate, highlighting its utility for eco-friendly pharmaceutical quality control.

Key Points

To develop and validate an analytical quality by design-driven, eco-friendly HPLC method for simultaneously quantifying pravastatin, rosuvastatin, atorvastatin, and fenofibrate in bulk and solid dosage forms.
Optimized chromatographic conditions via central composite design using a Waters Sunfire C18 column (150 × 4.6 mm, 5 µm), an isocratic mobile phase of 0.1% acetic acid:acetonitrile (23:77 v/v) at 0.9 mL/min, and UV detection at 250 nm.
Validated the procedure in accordance with ICH Q2(R2) guidelines and evaluated environmental sustainability using analytical Eco-Scale, GAPI, AGREE, RAPI, BAGI, and AGSA metrics.
Achieved baseline separation of all four drugs within 10 min with high linearity (R² > 0.999) and mean recovery rates ranging from 98.21% to 99.67%.
Scored an analytical Eco-Scale rating of 90, confirming an eco-friendly analytical profile that minimizes hazardous solvent consumption and energy use while successfully analyzing commercial binary tablets.

Cite This Study

Bukkapatnam et al. (2026) studied this question.

synapsesocial.com/papers/6a9935d8636c6408cfa7e68d https://doi.org/10.1002/sscp.70295

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September 3, 2026Separation Science PlusOpen Access

Multicomponent Analysis of Antihyperlipidemic Drugs: Integrating Analytical Quality by Design and Multi‐Metric Green Liquid Chromatography

View Full Paper

Ask AI

Bookmark

Authors

BBukkapatnamGITAM University RSRaja SundararajanAndhra University

Discussion

Member takes

Implication

Methodological study demonstrates rapid, sustainable chromatographic separation of statins and fenofibrate, highlighting its utility for eco-friendly pharmaceutical quality control.

Key Points

To develop and validate an analytical quality by design-driven, eco-friendly HPLC method for simultaneously quantifying pravastatin, rosuvastatin, atorvastatin, and fenofibrate in bulk and solid dosage forms.
Optimized chromatographic conditions via central composite design using a Waters Sunfire C18 column (150 × 4.6 mm, 5 µm), an isocratic mobile phase of 0.1% acetic acid:acetonitrile (23:77 v/v) at 0.9 mL/min, and UV detection at 250 nm.
Validated the procedure in accordance with ICH Q2(R2) guidelines and evaluated environmental sustainability using analytical Eco-Scale, GAPI, AGREE, RAPI, BAGI, and AGSA metrics.
Achieved baseline separation of all four drugs within 10 min with high linearity (R² > 0.999) and mean recovery rates ranging from 98.21% to 99.67%.
Scored an analytical Eco-Scale rating of 90, confirming an eco-friendly analytical profile that minimizes hazardous solvent consumption and energy use while successfully analyzing commercial binary tablets.

Cite This Study

Bukkapatnam et al. (2026) studied this question.

synapsesocial.com/papers/6a9935d8636c6408cfa7e68d https://doi.org/10.1002/sscp.70295

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