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Comparative preclinical study reveals Kaempferia parviflora restores UCP-1 expression in cell and mouse models, indicating the in vitro system validly mimics obesity-linked inflammation.
Macrophage-conditioned medium models are widely used in obesity research, but correspondence with obese animals has not been examined. We compared the effects of Kaempferia parviflora in this model and KK-Ay diabetic obese model mice. Anti-inflammatory effects and restoration of uncoupling protein-1 (UCP-1) expression were observed in both models, indicating that the macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression.
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Takahashi et al. (2026) studied this question.
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