Molecular virulence mechanism of phospholipase C from Pseudomonas aeruginosa

Q: What does this research mean for the field?

Phospholipase C contributes to the virulence of Pseudomonas aeruginosa through a specific molecular mechanism. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Nishika Sabharwal; Ge Yang; Michele Lunelli; Udom Sae-Ueng; Cy M. Jeffries; S.D. Chatziefthimiou; Sukrit Srivastava; Aziz Tumeh; André Geisler; Michael Kolbe; Jörg Labahn

doi:10.1093/procel/pwag062

September 1, 2026Protein & CellOpen Access

Molecular virulence mechanism of phospholipase C from Pseudomonas aeruginosa

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Key Points

Investigate the molecular mechanisms through which phospholipase C mediates cytotoxicity and virulence in Pseudomonas aeruginosa infections.
Characterized the structural and functional properties of phospholipase C from Pseudomonas aeruginosa.
Assessed molecular interactions between the bacterial enzyme and host membrane substrates using biochemical techniques.
Identified key structural domains essential for the catalytic activity and membrane-binding capability of phospholipase C.
Elucidated the molecular pathway by which enzymatic cleavage of host membrane phospholipids promotes cellular damage and bacterial survival.

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Implication

Biochemical analysis reveals virulence mechanisms of phospholipase C in Pseudomonas aeruginosa, highlighting pathways for targeted therapeutic development.

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Cite This Study

Sabharwal et al. (2026) studied this question.

synapsesocial.com/papers/6a9935e5636c6408cfa7e841 https://doi.org/10.1093/procel/pwag062

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Molecular virulence mechanism of phospholipase C from Pseudomonas aeruginosa

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Molecular virulence mechanism of phospholipase C from Pseudomonas aeruginosa

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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